![]() | Chronic kidney disease (CKD) is a worldwide public health problem and is now recognized as a common condition that is associated with an increased risk of cardiovascular disease and chronic renal failure (CRF).
The Kidney Disease Outcomes Quality Initiative (K/DOQI) of the National Kidney Foundation (NKF) defines chronic kidney disease as either kidney damage or a decreased kidney glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m2 for 3 or more months. Whatever the underlying etiology, the destruction of renal mass with irreversible sclerosis and loss of nephrons leads to a progressive decline in GFR. The different stages of chronic kidney disease form a continuum in time; prior to February 2002, no uniform classification of the stages of chronic kidney disease existed. At that time, K/DOQI published a classification of the stages of chronic kidney disease, as follows:
- Stage 1: Kidney damage with normal or increased GFR (>90 mL/min/1.73 m2)
- Stage 2: Mild reduction in GFR (60-89 mL/min/1.73 m2)
- Stage 3: Moderate reduction in GFR (30-59 mL/min/1.73 m2)
- Stage 4: Severe reduction in GFR (15-29 mL/min/1.73 m2)
- Stage 5: Kidney failure (GFR less than 15 mL/min/1.73 m2 or dialysis)
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